Can molecules that protect plants protect animals too? It seems they can and may be very beneficial in treating canine osteosarcoma.
Resveratrol, a polyphenol / antioxidant, produced by a number of plants, including grapes, peanuts and raspberries, is not only a potent anti-ager, but according to the National Cancer Institute, resveratrol may be an effective chemopreventive agent in three stages of cancer: initiation, promotion, and progression.
What does Hormetic Mean?
A hormetic is a substance produced by a plant in response to stressors like insects, bacteria, fungus, bacteria, and excessive heat and sunlight. It stimulates the plant’s defenses with nontoxic amounts of a toxic agent to protect the plant from infection and damage. Interestingly, when animals grazing on the plants, take in those substances they too are protected.
The Theory of Zenohormesis
The above phenomenon gave rise to the theory of zenohormesis: zeno meaning foreign, or consisting of foreign material, and hormesis meaning stimulation by nontoxic amounts of a toxic agent. The theory not only includes animals who graze on the plants themselves, but also refers to concentrated amounts of the substance(s) included in supplements. In 2006, Harvard scientists began referring to resveratrol as a hormetic.
How does Resveratrol Work?
Hormetics, natural plant-derived compounds like resveratrol, kick-start processes within the animals’ own cells and organs to actually attack disease or protect against harmful environmental factors.
One way resveratrol protects animals is by preventing and reducing inflammation. It does this by suppressing certain proteins produced by the body in response to infection, injury, and other stresses.
We now know that inflammation is the underlying cause of many diseases rather than a symptom of a disease as we once thought. Strong evidence points to inflammation as a key player in autoimmune diseases like arthritis, allergies and multiple sclerosis, as well as many others including diabetes, heart disease, and Alzheimer’s.
The way resveratrol attacks cancer is by selective intelligence, affecting cells through a number of different actions. Unlike anti-cancer drugs, It blocks the growing small blood vessels that feed a tumor, without stimulating metastasis (tumor spread to other areas of the body)
It also activates Tumor Necrosis Factor (TNF), an important immune system molecule that characterizes and suppresses NF-kB, a protein which is linked to almost all cancers in humans.
Many of resveratrol’s anti-cancer effects are the very same that pharmaceutical companies are spending billions of dollars to reproduce in new pharmaceuticals.
Unhappily, many of the more effective tumor drugs in use are also highly poisonous to the patient. Most often, the race is on between the toxic effects of the drugs and the growth and metastasis of the tumor.
An oncologist at M.D, Anderson Hospital in Houston in private conversation said, “Very few people are actually dying of cancer these days. With aggressive treatments such as chemo, radiation and surgery, most die of the therapy first or if they are lucky, they survive both the cancer and the treatment.”
More data is needed to say definitively that resveratrol is the answer to canine osteosarcoma. But trans-resveratrol, a pure form of resveratrol, has been shown to reverse some osteosarcoma lines and is well worth including in your canine osteosarcoma arsenal.
For a suggested therapeutic protocol and canine dosage, based what is known today via more than 4000 studies to date.